Brieño-Enríquez and his colleagues at University of Barcelona studied the effect of BPA on fetal development. 21 510 human fetal oocytes from 12 cultured ovaries were analyzed for the recombination and synapsis changes by immunofluorescence. The survival rate of the oocytes were also looked at. It was found that the BPA concentration of 1uM or higher increases the degeneration of oocytes five times, and the number of crossover markers during meiosis increased after exposed to BPA. This could be a link between “meiotic anomalies, recurrent miscarriage, and abnormal karyotypes” during critical period of pregnancy and BPA consumption.
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